Copper Free Click Chemistry Linkers

Copper free click chemistry linkers have been widely used for in vivo bioconjugation applications. Conventional "Click Chemistry" requires the presence of cytotoxic of Cu(I) catalyst, which limits its applications in biological systems. The Copper-free Click Chemistry is based on the reaction of a cyclooctyne (DBCO and BCN) moiety with an azide-labeled reaction partner, known as strain-promoted alkyne azide cycloaddition (SPAAC).

CAT#	Name	Formula	M.W.	Purity	Price
AP10693	4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenol	C₉H₈N₄O	188.19	95%	$378.00–$885.00	View
AP10141	Aminooxy-PEG2-TCO HCl Salt in solution	C₁₇H₃₁N₃O₆	373.45	95%	$750.00–$3380.00	View
AP10613	BCN-O-Acetic Acid NHS Ester	C₁₆H₁₉NO₅	305.33	95%	$980.00–$2580.00	View
AP10233	BCN-OH	C₁₀H₁₄O	150.22	95%	$310.00–$880.00	View
AP10611	BCN-PEG1-OH	C₁₂H₁₈O₂	194.27	95%	$980.00–$2480.00	View
AP10612	BCN-PEG1-OTs	C₁₉H₂₄O₄S	348.46	95%	$980.00–$2580.00	View
AP10711	BCN-PEG2-TAMRA	C₄₂H₄₈N₄O₈	736.85	95%	$2950.00–$5900.00	View
AP15563	BCN-PEG6-Maleimide	C₃₂H₄₉N₃O₁₁	651.754	95%	$680.00–$1980.00	View
AP10739	BCN-endo-PEG3-Maleimide	C₂₆H₃₇N₃O₈	519.59	95%	$480.00–$1680.00	View
AP10738	BCN-exo-PEG7-Maleimide	C₃₄H₅₃N₃O₁₂	695.80	95%	$680.00–$1680.00	View
AP10616	Bis-BCN-PEG1-diamide	C₂₈H₄₀N₂O₅	484.64	95%	$490.00–$1880.00	View
AP10617	Bis-BCN-PEG3-diamide	C₃₂H₄₈N₂O₇	572.74	95%	$430.00–$1880.00	View
AP10609	Boc-HyNic-PEG2-Amino-DBCO	C₃₆H₄₂N₆O₇	670.76	95%	$380.00–$1380.00	View
AP10677	BocNH-PEG3-acid-amine DBCO	C₃₂H₄₁N₃O₇	579.29	95%	$430.00–$1880.00	View
AP10140	Bocaminooxy-PEG2-BCN	C₂₄H₃₉N₃O₈	497.58	95%	$700.00–$3150.00	View
AP10303	DBCO-Biotin	C₂₈H₃₀N₄O₃S	502.63	95%	$1260.00–$2260.00	View
AP10757	DBCO-C4-PEG3-amine	C₂₇H₃₃N₃O₅	479.57	95%	$350.00–$890.00	View
AP10301	DBCO-COONHS Ester	C₂₈H₂₇N₃O₆	501.53	95%	$660.00–$2970.00	View
AP10300	DBCO-Mal	C₂₅H₂₁N₃O₄	427.45	95%	$139.00–$1780.00	View
AP10324	DBCO-NH-PEG12-Biotin	C₅₅H₈₃N₅O₁₆S	1102.34	95%	$310.00–$2960.00	View
AP10312	DBCO-NH-PEG12-acid	C₄₈H₇₂N₂O₁₇	949.09	95%	$220.00–$2000.00	View
AP10321	DBCO-NH-PEG2-Biotin	C₃₅H₄₃N₅O₆S	661.81	95%	$130.00–$2780.00	View
AP10313	DBCO-NH-PEG2-Mal	C₃₂H₃₄N₄O₇	586.64	95%	$210.00–$2480.00	View
AP10309	DBCO-NH-PEG3-acid	C₂₈H₃₂N₂O₇	508.56	95%	$155.00–$1765.00	View
AP10322	DBCO-NH-PEG4-Biotin	C₃₉H₅₁N₅O₈S	749.92	95%	$79.00–$2800.00	View
AP10678	DBCO-NH-PEG4-NH-Boc	C₃₄H₄₅N₃O₈	623.74	95%	$280.00–$850.00	View
AP10318	DBCO-NH-PEG5-NHS ester	C₃₆H₄₃N₃O₁₁	693.74	95%	$175.00–$1900.00	View
AP10323	DBCO-NH-PEG6-Biotin	C₄₃H₅₉N₅O₁₀S	838.02	95%	$190.00–$2840.00	View
AP10315	DBCO-NH-PEG6-Mal	C₄₀H₅₀N₄O₁₁	762.85	95%	$200.00–$2500.00	View
AP10030	DBCO-PEG3-CH2CO-NHS ester	C₃₁H₃₃N₃O₉	591.61	98%	$300.00–$1440.00	View
AP10749	DBCO-PEG3-propionic-Val-Cit-PAB	C₄₆H₅₉N₇O₁₀	870.02	95%	$980.00–$2940.00	View
AP10750	DBCO-PEG4-acetic-Val-Cit-PAB	C₄₅H₅₇N₇O₁₀	855.99	95%	$790.00–$2360.00	View
AP10756	DBCO-PEG4-alcohol	C₂₉H₃₆N₂O₆	508.61	95%	$110.00–$1400.00	View
AP10026	DBCO-acid C6	C₂₁H₁₉NO₃	333.38	98%	$260.00–$4250.00	View
AP10136	HyNic PEG2 BCN	C₂₆H₃₇N₅O₅	499.60	95%	$700.00–$3150.00	View
AP10057	Mal-PEG3-azide	C₁₂H₁₈N₄O₅	298.30	95%	$820.00–$1310.00	View
AP10717	Methyltetrazine-PEG4-Azide	C₁₇H₂₃N₇O₄	389.41	95%	$138.00–$630.00	View
AP10721	Methyltetrazine-PEG4-Maleimide	C₂₄H₃₀N₆O₇	514.53	95%	$155.00–$3328.00	View
AP10720	Methyltetrazine-PEG4-NHS ester	C₂₄H₃₁N₅O₉	533.53	95%	$154.00–$2250.00	View
AP10719	Methyltetrazine-PEG4-amine HCl Salt	C₁₇H₂₅N₅O₄	399.5	95%	$95.00–$1780.00	View
AP10718	Methyltetrazine-PEG5-Alkyne	C₂₀H₂₆N₄O₅	402.45	95%	$95.00–$495.00	View
AP10688	Methyltetrazine-acid	C₁₁H₁₀N₄O₂	230.22	95%	$125.00–$1115.00	View
AP10557	Norbornene-PEG3 acetic acid	C₁₆H₂₅NO₆	327.37	95%	$420.00–$1920.00	View
AP10560	Norbornene-PEG4 acetic acid	C₁₈H₂₉NO₇	371.43	95%	$420.00–$1920.00	View
AP10558	Norbornene-PEG4 acid	C₁₉H₃₁NO₇	385.45	95%	$360.00–$1470.00	View
AP10144	SPDP-NH-PEG2-TCO	C₂₃H₃₅N₃O₅S₂	497.67	95%	$780.00–$3510.00	View
AP10039	TCO PEG3 CH2CO2H	C₁₇H₂₉NO₇	359.42	98%	$440.00–$2480.00	View
AP10600	TCO-Acetic acid	C₁₀H₁₆O₃	184.24	95%	$680.00–$2280.00	View
AP10034	TCO-OH (axial)	C₈H₁₄O	126.2	98%	$318.00–$1750.00	View
AP10033	TCO-OH (equatorial)	C₈H₁₄O	126.2	98%	$480.00–$1720.00	View