DBCO-Mal

DBCO-Mal (Dibenzocyclooctyne-Maleimide, or DBCO-Maleimide) is a powerful reagent for copper-free click chemistry and thiol-specific conjugation. It combines a DBCO group for rapid reaction with azides and a maleimide group that targets thiol groups on cysteine residues.

Key Features:

• DBCO Group: Reacts quickly with azides, enabling copper-free and biocompatible labeling.
• Maleimide Group: Binds selectively to thiol groups, perfect for targeting cysteine residues in proteins.
• Dual Functionality: Offers flexible labeling options for proteins, peptides, and other biomolecules.

Applications:

1. Bioconjugation: Efficiently labels proteins and peptides through targeted reactions with azides and thiols.
2. Drug Delivery: Connects therapeutic agents to specific biomolecules for precise delivery.
3. Live-Cell Imaging: Facilitates safe labeling without the need for copper, suitable for live-cell and in vivo applications.

Benefits:

• Copper-Free: Safe for sensitive biological environments; no toxic catalysts required.
• Thiol-Specific: Precisely targets cysteine residues, enhancing conjugation accuracy.
• Versatile: DBCO-Mal supports dual-targeting strategies, expanding its use in biotech and pharmaceuticals.

Storage and Handling:

• Store at -20°C in a dry, inert environment.
• Handle with standard safety precautions for reactive chemicals.

DBCO-Mal delivers high reactivity and versatility, making it essential for bioconjugation, molecular biology, and targeted drug delivery.