Norbornene-PEG4 acid

Norbornene-PEG4 acid

This high-purity heterobifunctional PEG linker features a norbornene group for rapid, catalyst-free bioorthogonal ligation via inverse electron-demand Diels–Alder (IEDDA) cycloaddition with tetrazines, and a terminal carboxylic acid for amide coupling to amines or other nucleophiles. The PEG4 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling efficient and orthogonal bioconjugation in both aqueous and organic systems.

Key Features and Benefits

• Norbornene Group – Enables rapid, catalyst-free tetrazine ligation for bioorthogonal labeling.

• Carboxylic Acid Group – Allows versatile amide coupling with a variety of nucleophiles.

• PEG4 Spacer – Improves solubility and accessibility while minimizing steric hindrance.

• Orthogonal Reactivity – Supports sequential, site-specific modifications without cross-reactivity.

• High Purity – Supplied at >95% purity for consistent, reproducible results.

Applications

• Protein, peptide, and antibody modification

• Dual-functional linker for orthogonal conjugation

• Antibody–drug conjugate (ADC) linker chemistry

• Multifunctional imaging and diagnostic probe synthesis

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light

• Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to maintain reactivity

This product links norbornene and carboxyl functionalities through PEG4 for improved solubility and flexibility, especially ideal for precise orthogonal bioconjugation.