DBCO-NH-PEG4-NH-Boc

DBCO-NH-PEG4-NH-Boc

This product is a high-purity heterobifunctional PEG linker featuring a DBCO group for copper-free click chemistry and a Boc-protected amine for orthogonal conjugation, specifically connected by a PEG4 spacer for solubility and flexibility.

Key Features and Benefits

• DBCO Group – Enables rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides.

• Boc-Protected Amine – Provides a latent amine handle that can be deprotected under acidic conditions for selective conjugation.

• PEG4 Spacer – Improves solubility, reduces steric hindrance, and enhances molecular accessibility.

• High Purity – Suitable for bioorthogonal chemistry, dual labeling, and advanced drug conjugation strategies.

Applications

• Copper-free click conjugation with azide-modified biomolecules

• Orthogonal dual-labeling strategies via amine deprotection

• Bioconjugation for antibody, peptide, and protein functionalization

• Use in drug delivery, diagnostics, and probe development

Storage & Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.

This product combines copper-free click reactivity and a Boc-protected amine handle on a PEG4 spacer, specifically providing solubility, flexibility, and precise control for orthogonal conjugation workflows.