DBCO-NH-PEG6-Mal

DBCO-NH-PEG6-Mal

This product is a heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group for copper-free SPAAC click chemistry and a maleimide group for selective thiol conjugation. The PEG6 spacer provides hydrophilicity and flexibility, making it especially effective for dual-functional bioconjugation, probe development, and ADC design.

Key Features and Benefits:

• DBCO Group: Enables rapid, catalyst-free SPAAC click chemistry with azides.

• Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.

• PEG6 Spacer: Enhances solubility, flexibility, and steric accessibility.

• Dual Reactivity: Supports orthogonal, multifunctional conjugation strategies.

• High Purity: Ensures reproducibility in advanced research and therapeutic workflows.

Applications:

• Bioconjugation: Links biomolecules via thiol and azide/alkyne handles.

• ADC Development: Provides dual-reactive linker systems for antibody–drug conjugates.

• Probe Development: Builds multifunctional probes for imaging and diagnostics.

• Drug Delivery: Improves solubility and circulation properties of therapeutic conjugates.

Storage and Handling:

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature hydrolysis of maleimide.

This product integrates copper-free click chemistry with thiol conjugation in a PEG6 scaffold, specifically providing solubility, versatility, and dual reactivity for advanced bioconjugation.