Methyltetrazine-acid

Methyltetrazine-acid

This product is a small-molecule building block containing a reactive methyltetrazine group and a terminal carboxylic acid. It specifically enables rapid inverse electron-demand Diels–Alder (IEDDA) reactions with trans-cyclooctene (TCO) and supports amide coupling for versatile bioconjugation.

Key Features and Benefits

• Methyltetrazine Group: Reacts rapidly with TCO in bioorthogonal IEDDA click chemistry.

• Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.

• Compact Design: Provides minimal steric hindrance for conjugation.

• Bioorthogonal Reactivity: Performs selectively in complex biological environments.

• High Purity: Ensures reproducibility in bioconjugation workflows.

Applications

• Bioconjugation: Links TCO-modified biomolecules through rapid tetrazine chemistry.

• Probe Development: Builds click-enabled probes for imaging and diagnostics.

• Drug Delivery: Provides a scaffold for targeted therapeutic conjugates.

• Organic Synthesis: Serves as a versatile intermediate in linker design.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.

This product integrates rapid click reactivity with carboxyl functionality, specifically offering a compact and efficient scaffold for conjugation and synthesis.