BocNH-PEG3-acid-amine DBCO

BocNH-PEG3-acid-amine DBCO

This product is a multifunctional PEG linker that combines a dibenzocyclooctyne (DBCO) group, a PEG3 spacer, a Boc-protected amine, and a terminal carboxylic acid. It specifically enables copper-free click chemistry with azides, orthogonal amine conjugation after deprotection, and amide bond formation.

Key Features and Benefits

• DBCO Group: Supports strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.

• PEG3 Spacer: Improves solubility and reduces steric hindrance.

• Boc-Protected Amine: Provides orthogonal reactivity upon selective deprotection.

• Carboxylic Acid: Couples efficiently with amines for stable amide bonds.

• Multifunctional Design: Combines three orthogonal chemistries in one linker.

Applications

• Bioconjugation: Links azide-, amine-, and carboxyl-containing biomolecules.

• Probe Development: Builds multifunctional probes with dual click and amide handles.

• Drug Delivery: Provides PEGylated scaffolds with multiple reactive sites.

• Material Science: Functionalizes polymers and nanoparticles with versatile chemistries.

Storage and Handling

• Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.

This product integrates copper-free click reactivity, amide coupling, and orthogonal amine chemistry into a PEG3 scaffold, providing an especially versatile tool for multifunctional linker design.