Methyltetrazine-PEG4-Maleimide

Methyltetrazine-PEG4-Maleimide

This product is a bifunctional PEG linker containing a methyltetrazine group, a PEG4 spacer, and a maleimide group. It enables rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry with trans-cyclooctene (TCO) and selective thiol coupling, making it an especially versatile tool for dual bioconjugation.

Key Features and Benefits

• Methyltetrazine Group: Reacts rapidly with TCO in bioorthogonal click chemistry.

• Maleimide Group: Couples selectively with thiols to form stable thioether bonds.

• PEG4 Spacer: Improves solubility and reduces steric hindrance.

• Dual Reactivity: Combines tetrazine–TCO click and thiol-selective chemistry.

• High Purity: Ensures reproducibility in bioconjugation workflows.

Applications

• Bioconjugation: Links thiol-containing biomolecules with TCO-modified partners.

• Probe Development: Builds dual-functional probes for imaging and diagnostics.

• Drug Delivery: Provides PEGylated scaffolds with orthogonal conjugation handles.

• Material Science: Functionalizes polymers and nanoparticles with versatile chemistries.

Storage and Handling

• Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.

This product integrates tetrazine click reactivity with thiol–maleimide conjugation in a PEG4 scaffold, providing a powerful linker for multifunctional bioconjugation strategies.