DBCO-NH-PEG5-NHS ester

DBCO-NH-PEG5-NHS ester

This product is a heterobifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG5 spacer, and an NHS ester. It specifically enables copper-free click chemistry and amine conjugation, offering solubility, medium spacing, and dual reactivity.

Key Features and Benefits

• DBCO Group: Reacts rapidly with azides via SPAAC copper-free click chemistry.

• NHS Ester: Couples efficiently with primary amines to form stable amide bonds.

• PEG5 Spacer: Provides solubility, flexibility, and reduced steric hindrance.

• Dual Reactivity: Combines copper-free click chemistry with amine coupling.

• High Purity: Ensures reproducibility in sensitive bioconjugation workflows.

Applications

• Bioconjugation: Links azide-modified and amine-containing biomolecules.

• Probe Development: Builds multifunctional probes for imaging and diagnostics.

• Drug Delivery: Provides PEG scaffolds with orthogonal handles.

• Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual chemistry.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.

This product integrates copper-free click chemistry with amine coupling in a PEG5 scaffold, specifically offering solubility, flexibility, and multifunctionality.