Methyltetrazine-PEG5-Alkyne

Methyltetrazine-PEG5-Alkyne CAS:1802907-97-6 is an innovative and versatile bioconjugation reagent, exhibiting a unique combination of functional groups. This bifunctional compound features a methyltetrazine moiety and an alkyne functional group, interconnected by a polyethylene glycol (PEG5) linker. The methyltetrazine moiety enables rapid and selective conjugation to strained alkenes and alkynes through inverse-electron demand Diels-Alder (IEDDA) reactions, also known as bioorthogonal click chemistry. The alkyne group allows for further conjugation to azide-bearing biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC), a well-established click chemistry reaction.

This dual-functional reagent is ideal for applications in pharmaceutical research and development, including the site-specific labeling of biomolecules, the creation of antibody-drug conjugates (ADCs), and the development of targeted drug delivery systems. Methyltetrazine-PEG5-Alkyne's unique reactivity and biocompatibility make it a valuable tool for modifying and tracking a wide range of biomolecules, including proteins, nucleic acids, and small molecules.