DBCO-NH-PEG4-Biotin

DBCO-NH-PEG4-Biotin

This product is a multifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG4 spacer, and a biotin moiety. It specifically enables copper-free click chemistry with azides and strong streptavidin binding in a soluble, flexible scaffold.

Key Features and Benefits

• DBCO Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).

• Biotin Moiety: Provides strong affinity binding to streptavidin and avidin systems.

• PEG4 Spacer: Enhances solubility and reduces steric hindrance.

• Dual Reactivity: Combines bioorthogonal click chemistry with biotin affinity capture.

• High Purity: Ensures reproducibility in sensitive conjugation workflows.

Applications

• Bioconjugation: Links azide-modified biomolecules with biotin-binding partners.

• Probe Development: Builds multifunctional probes for imaging and diagnostics.

• Drug Delivery: Provides scaffolds with orthogonal and affinity handles.

• Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual functionality.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.

This product integrates copper-free click chemistry with biotin–streptavidin binding in a PEG4 scaffold, specifically offering dual functionality for advanced conjugation and probe design.