Methyltetrazine-PEG4-NHS ester
| Catalog #: | AP10720 |
| Chemical Formula: | C24H31N5O9 |
| Molecular Weight: | 533.53 |
| CAS: | 1802907-92-1 |
| Purity: | 95% |
| Availability: | In Stock |
| SDS: | Download |
| Unit | Price (USD) | |
|---|---|---|
| 10mg | $154.00 | Request quote |
| 25mg | $292.00 | Request quote |
| 100mg | $655.00 | Request quote |
| 500mg | $1400.00 | Request quote |
| Each | $2250.00 | Request quote |
| Each | $169.00 | Request quote |
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Methyltetrazine-PEG4-NHS ester
This product is a heterobifunctional PEG linker containing a methyltetrazine group, a PEG4 spacer, and an NHS ester. It specifically enables rapid tetrazine–TCO click chemistry and efficient amine coupling, offering solubility and medium-length flexibility for bioconjugation and synthesis.
Key Features and Benefits
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Methyltetrazine Group: Reacts rapidly with trans-cyclooctene (TCO) in IEDDA click chemistry.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG4 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with amine conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links TCO-modified biomolecules with amine-containing partners.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEG scaffolds with click and amine handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual-reactive groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates methyltetrazine click chemistry with amine-reactive NHS ester in a PEG4 scaffold, specifically offering versatile dual functionality.