DBCO-PEG3-CH2CO-NHS ester

DBCO-PEG3-CH2CO-NHS ester

This product is a heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group for copper-free SPAAC click chemistry and an NHS ester for rapid amine coupling. The PEG3 spacer improves solubility and compact spacing, making it especially effective for dual-functional bioconjugation, probe design, and drug delivery.

Key Features and Benefits:

• DBCO Group: Enables catalyst-free SPAAC click reactions with azides.

• NHS Ester: Couples efficiently with primary amines under mild conditions.

• PEG3 Spacer: Provides solubility, hydrophilicity, and steric accessibility.

• Dual Reactivity: Combines bioorthogonal and amine-targeted conjugation.

• High Purity: Ensures reproducibility in advanced workflows.

Applications:

• Bioconjugation: Links azide- and amine-containing biomolecules.

• Probe Development: Builds multifunctional probes for imaging and diagnostics.

• Drug Delivery: Provides PEGylated scaffolds for targeted therapeutics.

• Material Science: Functionalizes polymers, nanoparticles, and advanced surfaces.

Storage and Handling:

• Storage: Store at –20 °C in a sealed, moisture- and light-protected container.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.

This product integrates bioorthogonal SPAAC reactivity with amine coupling in a PEG3 scaffold, specifically offering solubility and versatility for advanced conjugation strategies.