DBCO-PEG4-alcohol

DBCO-PEG4-alcohol CAS:1416711-60-8 is a highly effective click chemistry reagent designed to facilitate efficient bioconjugation in pharmaceutical research and development. This compound features a dibenzocyclooctyne (DBCO) moiety, a strained alkyne that readily participates in copper-free click chemistry reactions, such as the azide-alkyne cycloaddition. The copper-free nature of these reactions ensures minimal cytotoxicity and allows for bioorthogonal labeling in living systems.

The PEG4 linker is a tetraethylene glycol that connects the DBCO group to an alcohol (OH) functional group. This biocompatible and flexible spacer provides enhanced water solubility, reduced immunogenicity, and improved pharmacokinetic profiles, making it an ideal candidate for pharmaceutical applications.

DBCO-PEG4-alcohol finds extensive use in bioconjugation, drug delivery, and the synthesis of targeted drug conjugates. Its unique reactivity and functional groups enable efficient conjugation with azide-tagged biomolecules, such as proteins, peptides, and nucleic acids, without the need for complex purification steps.