TCO-OH (axial)

TCO-OH (axial)

TCO-OH (axial) is a high-purity strained cyclooctene derivative featuring an axial hydroxyl group specifically for versatile chemical modification. The trans-cyclooctene moiety specifically enables ultra-fast, catalyst-free inverse-electron-demand Diels–Alder (IEDDA) click reactions with tetrazines, ideal for bioorthogonal chemistry in living systems. The axial configuration offers distinct steric and reactivity properties that can especially enhance conjugation selectivity and kinetics.

Key Features and Benefits

• Strained TCO Moiety: Reacts rapidly and selectively with tetrazines in IEDDA click chemistry.

• Axial Hydroxyl Group: Versatile functional handle for derivatization via esterification, ether formation, or activation.

• Bioorthogonal Reactivity: Performs in aqueous and physiological environments without metal catalysts.

• Axial Configuration: Provides unique steric properties and potential kinetic advantages.

• High Purity: Supplied at >95% purity for reproducible, consistent performance.

Applications

• Bioorthogonal labeling and imaging in live cells or in vivo.

• Development of tetrazine-responsive probes and drug conjugates.

• Surface and polymer functionalization for materials science.

• Site-specific modification of biomolecules.

• Triggered release systems in drug delivery research.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents; avoid prolonged exposure to moisture and heat.

TCO-OH (axial) combines ultra-fast tetrazine click reactivity with a hydroxyl handle in an axial configuration, enabling especially versatile functionalization for bioorthogonal chemistry, materials science, and drug delivery.