Aminooxy-PEG2-TCO HCl Salt in solution

Aminooxy-PEG2-TCO HCl Salt (in solution)

This product is a heterobifunctional PEG linker containing an aminooxy group, a PEG2 spacer, and a trans-cyclooctene (TCO). Supplied as an HCl salt in solution, it specifically enables oxime ligation and rapid bioorthogonal click chemistry with tetrazines.

Key Features and Benefits

• Aminooxy Group: Couples with aldehydes or ketones to form stable oxime bonds.

• TCO Group: Reacts rapidly with tetrazines via IEDDA click chemistry.

• PEG2 Spacer: Enhances solubility while maintaining compact length.

• Dual Reactivity: Combines carbonyl ligation with bioorthogonal click chemistry.

• Solution Form: Convenient HCl salt solution ensures stability and immediate use.

Applications

• Bioconjugation: Links carbonyl- and tetrazine-modified biomolecules.

• Probe Development: Builds multifunctional probes for diagnostics and imaging.

• Drug Delivery: Provides PEG scaffolds with orthogonal reactivity.

• Chemical Biology: Enables bioorthogonal labeling in live-cell environments.

Storage and Handling

• Storage: Store at –20 °C in sealed vials; protect from light and moisture.

• Handling: Supplied in solution; avoid repeated freeze–thaw cycles.

This product integrates oxime ligation and tetrazine click chemistry in a PEG2 scaffold, specifically delivered in a stable solution form for immediate use.