Boc-HyNic-PEG2-Amino-DBCO

Boc-HyNic-PEG2-Amino-DBCO

This product is a PEG linker with a Boc-protected HyNic, PEG2 spacer, amine, and DBCO. The HyNic enables hydrazone coupling after deprotection, while the DBCO supports copper-free click chemistry. The PEG2 chain specifically improves solubility and reduces steric hindrance.

Key Features and Benefits

• Boc-Protected HyNic: Offers controlled activation for hydrazone conjugation with aldehydes or ketones.

• DBCO Group: Enables fast, copper-free SPAAC reactions with azides.

• PEG2 Spacer: Enhances solubility and minimizes steric hindrance in conjugation workflows.

• Dual Reactivity: Combines hydrazone ligation and click chemistry for multifunctional applications.

• High Purity: Produced to ≥95% purity for reliable and reproducible results.

Applications

• Bioconjugation: Couples aldehyde/ketone-functionalized biomolecules with azide-modified partners.

• Probe Development: Builds multifunctional probes for imaging, diagnostics, and target identification.

• Drug Delivery: Serves as a versatile linker for PEGylated therapeutics and ADC design.

• Chemical Biology: Enables orthogonal dual-labeling strategies in complex systems.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Deprotect Boc under standard acidic conditions before hydrazone coupling; prepare fresh solutions before use.

This product integrates Boc-protected hydrazone chemistry with copper-free DBCO click functionality, specifically providing a versatile tool for dual-reactive conjugation strategies in bioconjugation and therapeutic research.