Bis-BCN-PEG1-diamide

Bis-BCN-PEG1-diamide

This product is a homobifunctional PEG linker containing two bicyclo[6.1.0]nonyne (BCN) groups connected by a PEG1 diamide spacer. It specifically enables copper-free click chemistry with azides, offering compact, soluble, and highly reactive functionality for bioconjugation and materials science.

Key Features and Benefits

• Dual BCN Groups: React rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).

• PEG1 Diamide Spacer: Provides compact spacing, solubility, and biocompatibility.

• Homobifunctional Design: Enables symmetric crosslinking of azide-modified molecules.

• Copper-Free Chemistry: Suitable for live-cell and biological applications.

• High Purity: Ensures reproducibility in sensitive workflows.

Applications

• Bioconjugation: Crosslinks azide-modified proteins, peptides, or biomolecules.

• Probe Development: Builds multifunctional probes for imaging and diagnostics.

• Drug Delivery: Provides PEG scaffolds with dual bioorthogonal handles.

• Material Science: Functionalizes polymers, nanoparticles, and hydrogels with click-ready groups.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.

This product integrates dual BCN click handles with a PEG1 diamide spacer, specifically offering compact and efficient crosslinking for advanced conjugation.