DBCO-NH-PEG2-Biotin

DBCO-NH-PEG2-Biotin

This product is a multifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG2 spacer, and a biotin moiety. It specifically enables copper-free click chemistry with azides and high-affinity streptavidin binding in a compact, soluble scaffold.

Key Features and Benefits

• DBCO Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).

• Biotin Moiety: Provides strong affinity binding to streptavidin and avidin systems.

• PEG2 Spacer: Improves solubility while maintaining compact molecular spacing.

• Dual Reactivity: Combines bioorthogonal click chemistry with biotin affinity capture.

• High Purity: Ensures reproducibility in sensitive bioconjugation workflows.

Applications

• Bioconjugation: Links azide-modified biomolecules with biotin-binding systems.

• Probe Development: Builds multifunctional probes for imaging and diagnostics.

• Drug Delivery: Provides PEG scaffolds with click and affinity handles.

• Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual reactivity.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.

This product integrates copper-free click reactivity with biotin–streptavidin binding in a PEG2 scaffold, specifically offering versatility for conjugation and probe design.