BCN-OH

BCN-OH

This product is a high-purity strained cycloalkyne features a bicyclo[6.1.0]nonyne (BCN) for rapid, copper-free SPAAC with azides and a terminal hydroxyl for versatile derivatization. Ideal for live-cell labeling, surface functionalization, and drug delivery, the hydroxyl enables further modification via esterification, ether formation, or activation.

Key Features and Benefits

• BCN Group: Supports fast, copper-free click chemistry with azides for bioorthogonal labeling.

• Hydroxyl Group: Serves as a versatile site for further functionalization or linker attachment.

• Bioorthogonal Reactivity: Allows selective labeling in complex biological environments without toxic catalysts.

• Compact Design: Low steric hindrance ensures high reactivity and efficient conjugation.

• High Purity: Supplied at >95% purity for reproducible and consistent results.

Applications

• Bioorthogonal Labeling: Conjugate azide-containing biomolecules under physiological conditions.

• Protein and Peptide Modification: Introduce BCN groups to biomolecules for SPAAC reactions.

• Nanoparticle and Surface Functionalization: Attach BCN moieties to enable click chemistry-based surface engineering.

• Drug Delivery Systems: Create targeted delivery vehicles with clickable BCN handles.

• Chemical Biology Tools: Develop probes and sensors for live-cell imaging and diagnostics.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents such as DMF, DMSO, or dichloromethane; avoid prolonged exposure to moisture.

This high-purity strained cycloalkyne features a hydroxyl group, provides copper-free click reactivity with azides, and offers an especially versatile handle for chemical modification in bioorthogonal and materials science applications.