TCO-OH (equatorial)

TCO-OH (equatorial)

This product is a strained trans-cyclooctene derivative bearing a terminal hydroxyl group in the equatorial configuration. The TCO moiety enables ultrafast inverse-electron-demand Diels–Alder (IEDDA) click reactions with tetrazines, while the hydroxyl provides a versatile handle for further derivatization, making it especially ideal for bioorthogonal chemistry and probe development.

Key Features and Benefits:

• TCO Group: Highly strained alkene for rapid tetrazine ligation.

• Equatorial Hydroxyl: Provides a reactive site for further chemical modification.

• Bioorthogonal Reactivity: Supports in vitro and in vivo labeling under mild conditions.

• Compact Design: Minimal steric hindrance for efficient conjugation.

• High Purity: Ensures reproducibility in sensitive workflows.

Applications:

• Click Chemistry: Enables rapid IEDDA reactions with tetrazines for bioorthogonal labeling.

• Bioconjugation: Suitable for site-specific protein, peptide, or antibody modification.

• Probe Development: Useful in imaging agents, diagnostics, and theranostics.

• Synthetic Chemistry: Intermediate for functionalized TCO derivatives.

Storage and Handling:

• Storage: Store at –20 °C in a dry, light-protected container.

• Handling: Use anhydrous solvents (e.g., DMSO, DMF, acetonitrile) to maintain TCO stability; avoid prolonged exposure to light and heat.

This product offers ultrafast tetrazine reactivity and a hydroxyl handle in a compact strained alkene framework, making it a especially valuable reagent for bioorthogonal chemistry and advanced conjugation.