Norbornene-PEG4 acetic acid

Norbornene-PEG4-acetic acid

This product is a high-purity PEG linker with a terminal norbornene for bioorthogonal click reactions and a carboxylic acid group for amide coupling, specifically connected by a PEG4 spacer for solubility and flexibility.

Key Features and Benefits

• Norbornene Group – Enables rapid, bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) click reactions with tetrazines.

• Carboxylic Acid Group – Reactive site for amide bond formation with primary amines.

• PEG4 Spacer – Provides solubility, flexibility, and reduced steric hindrance in conjugates.

• High Purity – Suitable for drug delivery, click chemistry, and bioconjugation applications.

Applications

• Bioorthogonal labeling using tetrazine ligation

• Amide coupling to proteins, peptides, or antibodies

• Linker design for targeted therapeutics and antibody–drug conjugates

• Dual-functional probe and material surface modification

Storage & Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.

This product provides a norbornene group for tetrazine click chemistry and a carboxyl group for amide coupling, connected by a PEG4 spacer specifically to ensure solubility, flexibility, and efficient bioconjugation.