DBCO-PEG3-propionic-Val-Cit-PAB

DBCO-PEG3-propionic-Val-Cit-PAB

This product is a cleavable linker frequently used in antibody-drug conjugates (ADCs) and targeted drug delivery systems. Specifically, it combines a DBCO group for copper-free click chemistry, a PEG3 spacer to enhance solubility, and a Val-Cit-PAB moiety for controlled intracellular drug release. As a result, this reagent enables site-specific conjugation and cathepsin B-triggered payload release.

Key Features and Benefits:

• Click Chemistry Ready: DBCO allows rapid, copper-free reaction with azide-modified biomolecules.

• PEG3 Spacer: Improves solubility, reduces aggregation, and enhances biocompatibility.

• Val-Cit-PAB Cleavable Linker: Cathepsin B-sensitive dipeptide enables precise drug release inside target cells.

• Self-Immolative Mechanism: Ensures complete payload release following cleavage.

• ADC-Compatible: Widely used in antibody-drug conjugate development for cancer and immunotherapy applications.

Applications:

• Antibody-Drug Conjugates (ADCs): Facilitates stable conjugation and controlled release of cytotoxic agents.

• Targeted Drug Delivery: Enables selective drug activation in diseased cells.

• Click Chemistry Bioconjugation: Ideal for bioorthogonal labeling in live cell and in vivo environments.

• Preclinical Research: Validated linker design for use in therapeutic development pipelines.

Storage and Handling:

• Storage: Store at -20°C, protected from light and moisture.

• Handling: Use anhydrous solvents (e.g., DMSO, DMF); prepare fresh solutions to avoid hydrolysis.

DBCO-PEG3-propionic-Val-Cit-PAB offers efficient conjugation, excellent solubility, and reliable intracellular drug release, making it a powerful tool for advancing next-generation targeted therapeutics.