BCN-O-Acetic Acid NHS Ester

BCN-O-Acetic Acid NHS Ester

This product is a PEG-based linker containing a bicyclo[6.1.0]nonyne (BCN) group, an acetic acid linker, and an NHS ester. It enables copper-free click chemistry with azides and efficient amine conjugation specifically for dual-functional bioconjugation.

Key Features and Benefits

• BCN Group: Performs strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.

• NHS Ester: Couples efficiently with primary amines to form stable amide bonds.

• Acetic Acid Linker: Provides spacing and stability for dual reactivity.

• Dual Reactivity: Combines SPAAC click chemistry with amine coupling.

• High Purity: Ensures reproducibility in sensitive workflows.

Applications

• Bioconjugation: Links azide-modified biomolecules with amine-containing partners.

• Probe Development: Builds multifunctional probes for diagnostics and imaging.

• Drug Delivery: Provides PEG scaffolds with orthogonal handles.

• Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual-reactive groups.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.

This product integrates copper-free click reactivity with amine-reactive NHS chemistry, specifically providing a versatile scaffold for bioconjugation and probe design.