Pentanamide, 5-azido-N-[4-(2-cyanoethynyl)-phenyl]

Pentanamide, 5-azido-N-[4-(2-cyanoethynyl)-phenyl]

Pentanamide, 5-azido-N-[4-(2-cyanoethynyl)-phenyl] is a high-purity heterobifunctional reagent featuring an azide group for copper-catalyzed (CuAAC) or strain-promoted (SPAAC) click chemistry and a cyanoethynyl moiety for cycloaddition or further derivatization. The pentanamide backbone specifically provides structural stability and a suitable linker length for efficient spatial positioning in conjugation reactions. This reagent is especially ideal for orthogonal labeling, probe synthesis, and advanced chemical biology applications.

Key Features and Benefits

• Azide Group: Compatible with CuAAC and SPAAC click chemistry for selective conjugation with alkynes.

• Cyanoethynyl Group: Offers unique reactivity for cycloaddition and functional probe design.

• Amide Linker: Provides stability and defined spacing between reactive groups.

• Orthogonal Design: Supports multi-step, site-specific modifications.

• High Purity: Supplied at >95% purity for reproducibility.

Applications

• Orthogonal chemical labeling strategies.

• Synthesis of multifunctional molecular probes.

• Bioconjugation for chemical biology and diagnostics.

• Nanoparticle and polymer functionalization.

• Medicinal chemistry research for linker design.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents; avoid moisture to maintain reactivity.

This product combines azide click chemistry and cyanoethynyl reactivity in a stable amide-linked scaffold for orthogonal bioconjugation and probe synthesis.