APN-Maleimide

APN-Maleimide

This product is a heterobifunctional linker containing an aminopropyl nitrile (APN) group and a maleimide moiety. It enables thiol-specific conjugation and orthogonal functionalization, specifically offering compact design, solubility, and dual reactivity for bioconjugation and synthesis.

Key Features and Benefits

• Maleimide Group: Couples selectively with thiols to form stable thioether bonds.

• APN Group: Provides an additional handle for orthogonal modifications.

• Compact Scaffold: Minimizes steric hindrance while maintaining reactivity.

• Dual Reactivity: Combines thiol conjugation with nitrile-based chemistry.

• High Purity: Ensures reproducibility in sensitive bioconjugation workflows.

Applications

• Bioconjugation: Links thiol-containing biomolecules with orthogonal partners.

• Probe Development: Builds multifunctional probes with thiol and nitrile reactivity.

• Drug Delivery: Provides scaffolds with thiol-specific handles for targeted conjugation.

• Organic Synthesis: Serves as a versatile intermediate for modular linker chemistry.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged moisture exposure.

This product integrates maleimide thiol chemistry with an aminopropyl nitrile group, specifically offering compact, soluble, and multifunctional reactivity for conjugation.