Biotin-PEG4-Hydrazide

Biotin-PEG4-Hydrazide

This product is a high-purity biotinylation reagent featuring a hydrazide functional group for conjugation with aldehydes and ketones, connected by a PEG4 spacer that specifically enhances solubility and reduces steric hindrance.

Key Features and Benefits

• Biotin Moiety – Provides strong, specific binding to streptavidin and avidin systems.

• Hydrazide Group – Reacts selectively with aldehydes and ketones to form stable hydrazone linkages.

• PEG4 Spacer – Improves solubility, flexibility, and accessibility of the biotin tag.

• High Purity – Ensures reliability for bioconjugation, labeling, and detection applications.

Applications

• Biotinylation of oxidized glycoproteins and polysaccharides

• Labeling of aldehyde- or ketone-containing biomolecules

• Probe and assay development in diagnostics

• Linker for drug delivery and capture systems

Storage & Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO) or aqueous buffer as needed. Avoid repeated freeze–thaw cycles.

This product enables efficient conjugation of biotin to aldehyde- and ketone-containing biomolecules via hydrazone formation. The PEG4 spacer specifically enhances solubility and reduces steric hindrance, making it ideal for bioconjugation, assay development, and drug delivery.