Biotin-PEG3-Hydrazide

Biotin-PEG3-Hydrazide

This product is a heterobifunctional PEG3 linker with a biotin moiety and a terminal hydrazide group. The PEG3 spacer provides solubility and flexibility, while the biotin ensures high-affinity binding to avidin/streptavidin systems and the hydrazide enables coupling with aldehydes and ketones for targeted conjugation.

Key Features and Benefits:

• Biotin Group: Strong binding to avidin and streptavidin proteins for affinity-based applications.

• Hydrazide Group: Reacts with aldehydes and ketones to form stable hydrazone linkages.

• PEG3 Spacer: Provides compact hydrophilicity and reduced steric hindrance.

• High Purity: Ensures reproducibility in bioconjugation workflows.

• Dual Functionality: Combines affinity labeling with chemoselective conjugation.

Applications:

• Bioconjugation: Enables biotinylation and aldehyde/ketone coupling of biomolecules.

• Affinity Labeling: Facilitates capture, detection, and purification with biotin tags.

• Drug Delivery: Improves solubility and enables biotin-mediated targeting.

• Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.

Storage and Handling:

• Storage: Store at –20 °C, protected from moisture and light.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain hydrazide stability.

This product offers dual reactivity with biotin targeting and hydrazide chemistry in a short PEG spacer, making it an especially powerful tool for conjugation and biomolecular labeling.