Biotin-PEG4-amine

Biotin-PEG4-amine

This product is a high-purity PEG linker combining a biotin group for strong, specific binding to streptavidin or avidin and a primary amine for versatile conjugation to activated esters or other electrophiles. The PEG4 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling especially efficient bioconjugation in aqueous and organic systems.

Key Features and Benefits

• Biotin Group – Provides high-affinity, specific binding to streptavidin/avidin for capture, detection, or immobilization.

• Primary Amine – Couples efficiently with NHS esters, activated acids, and other electrophiles.

• PEG4 Spacer – Improves aqueous solubility, molecular flexibility, and accessibility of reactive groups.

• Reduced Steric Hindrance – PEG spacer minimizes interference in binding and conjugation.

• High Purity – Supplied at >95% purity for reproducible and reliable results.

Applications

• Biotinylation of proteins, peptides, and antibodies

• Streptavidin-based capture, detection, and purification systems

• Surface and nanoparticle functionalization

• Diagnostic assays and biosensor development

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light

• Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure to preserve amine reactivity

This product combines strong streptavidin-binding biotin with a reactive primary amine, separated by a PEG4 spacer for solubility and flexibility, making it especially ideal for efficient biotinylation and bioconjugation.