Biotin-PEG11-amine

Biotin-PEG11-amine

This product is a heterobifunctional PEG11 linker containing a biotin moiety for avidin/streptavidin binding and a terminal primary amine for amide coupling. The PEG11 spacer specifically provides excellent hydrophilicity, flexibility, and extended spacing, ensuring high biotin accessibility in bioconjugation and labeling applications.

Key Features and Benefits:

• Biotin Group: Enables high-affinity binding to avidin and streptavidin systems.

• Amine Group: Couples efficiently with carboxyls, NHS esters, and other electrophiles.

• PEG11 Spacer: Enhances solubility, reduces steric hindrance, and improves biotin accessibility.

• High Purity: Ensures reproducibility in sensitive conjugation workflows.

• Dual Functionality: Combines affinity labeling with versatile amine reactivity.

Applications:

• Affinity Labeling: Biotinylation of proteins, peptides, and antibodies.

• Bioconjugation: Facilitates multifunctional linker strategies for dual labeling.

• Drug Delivery: PEGylated design improves solubility and targeting efficiency.

• Surface Functionalization: Functionalizes nanoparticles, hydrogels, and biosensor platforms.

Storage and Handling:

• Storage: Store at –20 °C in a sealed, light-protected container.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain amine stability.

This product combines biotin’s strong binding with amine-based conjugation in a long PEG spacer, making it an especially versatile tool for bioconjugation, drug delivery, and affinity capture.