TCO-PEG9-maleimide

TCO-PEG9-maleimide

This product is a bifunctional PEG9 linker with a trans-cyclooctene (TCO) for rapid tetrazine click chemistry and a maleimide group for thiol-specific conjugation. The PEG9 spacer provides hydrophilicity, flexibility, and reduced steric hindrance, making it especially ideal for orthogonal bioconjugation and drug delivery strategies.

Key Features and Benefits:

• TCO Group: Enables fast, bioorthogonal IEDDA click chemistry with tetrazines.

• Maleimide Group: Selectively conjugates with thiol groups in proteins or peptides.

• PEG9 Spacer: Enhances solubility and accessibility of reactive groups.

• High Purity: Ensures reproducibility in sensitive bioconjugation workflows.

• Dual Reactivity: Supports orthogonal and stepwise conjugation approaches.

Applications:

• Bioconjugation: Dual reactivity for combining thiol and tetrazine chemistry.

• Drug Delivery: Useful in linker-payload designs for targeted therapeutics.

• Antibody-Drug Conjugates (ADCs): Enables precise conjugation strategies.

• Surface Functionalization: Modify nanoparticles, hydrogels, or polymers.

Storage and Handling:

• Storage: Store at –20 °C, protected from moisture and light.

• Handling: Use anhydrous solvents (e.g., DMSO, DMF) to preserve maleimide and TCO stability.

This product provides orthogonal thiol and click-reactive handles with a hydrophilic PEG spacer, making it an especially versatile linker for advanced conjugation workflows.