This high-purity PEG linker features a TCO for rapid, catalyst-free IEDDA cycloaddition with tetrazines and a maleimide for selective thiol coupling. Its short PEG1 spacer specifically enhances solubility, reduces steric hindrance, and maintains a compact structure for efficient, orthogonal bioconjugation.
TCO-PEG1-amido maleimide
| Catalog #: | AP10801 |
| Chemical Formula: | C20H29N3O6 |
| Molecular Weight: | 407.46 |
| CAS: | 2755594-29-5 |
| Purity: | 95% |
| Availability: | In Stock |
| SDS: | Download |
| Unit | Price (USD) | |
|---|---|---|
| 10 mg | $180.00 | Request quote |
| 25 mg | $320.00 | Request quote |
Would you like to inquire about bulk pricing?
TCO-PEG1-Amido Maleimide
Key Features and Benefits
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TCO Group – Enables ultra-fast, catalyst-free tetrazine ligation for bioorthogonal labeling.
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Maleimide Group – Reacts selectively with sulfhydryl groups via Michael addition under mild conditions.
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PEG1 Spacer – Improves solubility and reduces steric hindrance while keeping linker length minimal.
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Orthogonal Reactivity – Allows sequential modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible performance.
Applications
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Dual-functional linker for orthogonal conjugation
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Protein, peptide, and antibody modification
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Antibody–drug conjugate (ADC) linker design
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Multifunctional imaging and diagnostic probe development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure to preserve reactivity
This product combines tetrazine ligation via TCO with thiol–maleimide conjugation, connected by a PEG1 spacer for solubility and minimal steric hindrance, making it especially ideal for precise, orthogonal bioconjugation.
Related Products
| CAT# | Name | M.W. | Purity | Price |
|---|---|---|---|---|
| AP15563 | BCN-PEG6-Maleimide | 651.754 | 95% | $680.00–$1980.00 |
| AP11029 | TCO-PEG5-BCN | 608.76 | 95% | $580.00–$1680.00 |
| AP10806 | TCO-PEG6-amido maleimide | 627.72 | 95% | $180.00–$320.00 |
| AP10805 | TCO-PEG5-amido maleimide | 583.67 | 95% | $320.00–$1480.00 |
| AP10804 | TCO-PEG4-amido maleimide | 539.62 | 95% | $180.00–$320.00 |
| AP10803 | TCO-PEG3-amido maleimide | 495.57 | 95% | $180.00–$320.00 |
| AP10802 | TCO-PEG2-amido maleimide | 451.51 | 95% | $320.00–$1480.00 |
| AP10756 | DBCO-PEG4-alcohol | 508.61 | 95% | $110.00–$1400.00 |