TCO-PEG5-BCN

TCO-PEG5-BCN

This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) for ultrafast tetrazine ligation and a bicyclononyne (BCN) for copper-free SPAAC click chemistry. The PEG5 spacer provides solubility, flexibility, and spacing, making this dual-reactive linker especially ideal for multifunctional bioconjugation, probe design, and therapeutic development.

Key Features and Benefits:

• TCO Group: Enables rapid, catalyst-free IEDDA reactions with tetrazines.

• BCN Group: Supports SPAAC click chemistry with azides.

• PEG5 Spacer: Improves solubility, hydrophilicity, and steric accessibility.

• Dual Reactivity: Combines two orthogonal click handles in one scaffold.

• High Purity: Ensures reproducibility in advanced bioconjugation workflows.

Applications:

• Bioorthogonal Labeling: Enables dual orthogonal conjugation strategies in vitro and in vivo.

• ADC Development: Useful in designing multifunctional antibody–drug conjugates.

• Probe Development: Builds dual-functional probes for imaging or diagnostics.

• Drug Delivery: Provides flexible PEGylated design for targeted conjugation.

Storage and Handling:

• Storage: Store at –20 °C in a moisture- and light-protected container.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect TCO from light to preserve reactivity.

This product integrates two powerful click handles with PEG-enhanced solubility, making it an especially versatile dual-functional linker for advanced bioconjugation and therapeutic research.