TCO-PEG5 acid

TCO-PEG5 acid

This product is a high-purity PEG linker with a trans-cyclooctene (TCO) group for rapid, catalyst-free inverse electron-demand Diels–Alder (IEDDA) cycloaddition with tetrazines and a terminal carboxylic acid for versatile coupling to amines or other nucleophiles. The PEG5 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling especially efficient bioconjugation in aqueous and organic media.

Key Features and Benefits

• TCO Group – Enables ultra-fast, catalyst-free tetrazine ligation for bioorthogonal conjugation.

• Carboxylic Acid – Couples efficiently to amines via carbodiimide or other activation chemistries.

• PEG5 Spacer – Improves aqueous solubility, flexibility, and accessibility of reactive groups.

• Orthogonal Reactivity – Allows sequential modifications without cross-reactivity.

• High Purity – Supplied at >95% purity for reproducible performance.

Applications

• Bioorthogonal labeling of proteins, peptides, and nucleic acids

• Antibody–drug conjugate (ADC) linker chemistry

• Multifunctional imaging and diagnostic probe development

• Surface modification of nanoparticles and biomaterials

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light

• Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure to preserve reactivity

This product combines ultra-fast tetrazine click chemistry via TCO with a reactive carboxylic acid, separated by a PEG5 spacer specifically for solubility and flexibility, enabling efficient and orthogonal bioconjugation.