TCO-PEG3-oxyamineBoc

TCO-PEG3-oxyamineBoc

This product is a high-purity heterobifunctional linker featuring a trans-cyclooctene (TCO) group for rapid bioorthogonal click reactions and a Boc-protected oxyamine for selective deprotection and further conjugation. The PEG3 spacer enhances solubility, flexibility, and accessibility in conjugation systems.

Key Features and Benefits

• TCO Moiety – Enables fast and efficient inverse-electron-demand Diels–Alder (IEDDA) reactions with tetrazines.

• Boc-Protected Oxyamine – Provides a stable masked reactive site, unmasked upon deprotection for conjugation with aldehydes or ketones.

• PEG3 Spacer – Improves water solubility, reduces steric hindrance, and increases linker flexibility.

• High Purity – Suitable for bioconjugation, probe development, and drug delivery.

Applications

• Bioorthogonal labeling via TCO–tetrazine click chemistry

• Conjugation to aldehyde- or ketone-containing biomolecules after Boc removal

• Development of imaging probes and therapeutic conjugates

• Spacer/linker for drug delivery and diagnostics

Storage & Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Use: Dissolve in anhydrous solvents (e.g., DMSO, DMF). Avoid repeated freeze–thaw cycles.

This product offers a TCO group for fast bioorthogonal conjugation and a Boc-protected oxyamine for selective carbonyl coupling, with a PEG3 spacer specifically for solubility and flexibility.