TCO-PEG3-oxyamine

TCO-PEG3-oxyamine

This product is a high-purity PEG linker with a trans-cyclooctene (TCO) group and a terminal oxyamine, specifically connected by a PEG3 spacer for solubility and flexibility.

Key Features and Benefits

• TCO Group – Enables rapid and bioorthogonal click reactions with tetrazines.

• Oxyamine Group – Reacts selectively with aldehydes and ketones to form stable oxime linkages.

• PEG3 Spacer – Improves solubility, reduces steric hindrance, and enhances accessibility in conjugates.

• High Purity – Suitable for bioconjugation, labeling, and advanced chemical biology workflows.

Applications

• Dual-functional linker for orthogonal bioconjugation

• Site-specific protein, peptide, or antibody modification

• Oxime ligation with aldehyde/ketone-functionalized biomolecules

• Tetrazine–TCO ligation for rapid click chemistry in vitro and in vivo

• Development of imaging probes, drug delivery systems, and diagnostics

Storage & Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.

This product combines a TCO group for fast tetrazine ligation and an oxyamine for oxime formation, linked via a PEG3 spacer for solubility and reduced steric hindrance. This dual-functional linker is especially ideal for orthogonal bioconjugation and chemical biology applications.