TCO-PEG3-CH2CONHS

TCO-PEG3-CH2CONHS

This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) group for rapid tetrazine ligation and an NHS ester for efficient amine coupling. The PEG3 spacer enhances solubility and compact spacing, making it especially useful for probe development, ADCs, and multifunctional bioconjugation.

Key Features and Benefits:

• TCO Group: Supports ultrafast, copper-free IEDDA click chemistry with tetrazines.

• NHS Ester: Couples efficiently with primary amines under mild conditions.

• PEG3 Spacer: Provides hydrophilicity and steric accessibility.

• Dual Reactivity: Enables simultaneous bioorthogonal and amine conjugation.

• High Purity: Ensures reproducibility in sensitive workflows.

Applications:

• ADC Development: Provides cleavable linkers for targeted therapeutic conjugates.

• Probe Development: Builds TCO-modified probes for imaging and diagnostics.

• Bioconjugation: Links biomolecules with bioorthogonal and amine handles.

• Drug Delivery: Enhances solubility and stability of conjugates.

Storage and Handling:

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO); prepare fresh solutions to minimize NHS hydrolysis.

This product combines rapid TCO ligation with amine-reactive NHS chemistry in a PEG3 scaffold, specifically providing compact and efficient conjugation strategies.