TCO-PEG2-oxyamineBoc

TCO-PEG2-oxyamineBoc

TCO-PEG2-oxyamineBoc is a high-purity heterobifunctional PEG linker featuring a trans-cyclooctene (TCO) group for rapid, catalyst-free bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) cycloaddition with tetrazines, and a Boc-protected oxyamine for controlled deprotection and subsequent oxime ligation with aldehyde or ketone groups. The PEG2 spacer improves solubility, enhances flexibility, and reduces steric hindrance, allowing especially efficient conjugation in both aqueous and organic systems.

Key Features

• TCO group for ultra-fast, catalyst-free IEDDA click chemistry with tetrazines

• Boc-protected oxyamine for selective deprotection and aldehyde/ketone conjugation

• PEG2 spacer enhances hydrophilicity and minimizes steric interference

• High chemical stability and purity

• Compatible with aqueous and organic solvents

Applications

• Site-specific biomolecule labeling

• Antibody–drug conjugate (ADC) development

• Sequential or orthogonal bioconjugation strategies

• Imaging probe synthesis and targeted drug delivery

Storage and Handling

• Store at –20 °C, protected from light and moisture

• Bring to room temperature before opening

• Avoid repeated freeze–thaw cycles

This product combines a TCO group for rapid tetrazine ligation with a Boc-protected oxyamine for controlled oxime formation, linked via a PEG2 spacer specifically for improved solubility and reduced steric hindrance.