TCO-PEG2-oxyamine

TCO-PEG2-oxyamine

This product is a bifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG2 spacer, and a terminal oxyamine. It enables rapid tetrazine click chemistry and selective oxime ligation with aldehydes or ketones, specifically providing versatile dual reactivity.

Key Features and Benefits

• TCO Group: Reacts rapidly with tetrazines via inverse-electron-demand Diels–Alder (IEDDA) click chemistry.

• Oxyamine Group: Couples with aldehydes or ketones to form stable oxime bonds.

• PEG2 Spacer: Enhances solubility while maintaining compact molecular size.

• Dual Reactivity: Combines click and carbonyl-reactive chemistries in one linker.

• High Purity: Ensures consistent results in bioconjugation workflows.

Applications

• Bioconjugation: Links aldehyde- or ketone-modified biomolecules with tetrazine partners.

• Probe Development: Builds multifunctional probes for imaging and diagnostics.

• Drug Delivery: Serves as a scaffold for dual-functional therapeutic conjugates.

• Material Science: Functionalizes surfaces and nanostructures with orthogonal chemistries.

Storage and Handling

• Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.

This product integrates TCO click reactivity with oxyamine–carbonyl conjugation in a PEG2 scaffold, specifically providing a compact and versatile tool for multifunctional conjugation strategies.