TCO-PEG1-OH (equatorial)

TCO-PEG1-OH (equatorial)

This high-purity PEG linker features an equatorial trans-cyclooctene (TCO) group for rapid, catalyst-free inverse electron-demand Diels–Alder (IEDDA) cycloaddition with tetrazines, and a terminal hydroxyl group for further chemical derivatization or conjugation. The short PEG1 spacer improves aqueous solubility, reduces steric hindrance, and maintains a compact structure, enabling especially efficient and orthogonal bioconjugation in both aqueous and organic systems.

Key Features and Benefits

• Equatorial TCO Group – Enables ultra-fast, catalyst-free tetrazine ligation for bioorthogonal labeling.

• Hydroxyl Group – Serves as a versatile handle for further functionalization or coupling.

• PEG1 Spacer – Improves solubility while minimizing steric hindrance and maintaining a compact structure.

• Orthogonal Reactivity – Supports sequential, site-specific modifications without cross-reactivity.

• High Purity – Supplied at >95% purity for reliable, reproducible performance.

Applications

• Protein, peptide, and antibody modification

• Bioorthogonal probe and imaging agent synthesis

• Precursor for multifunctional linker design

• Site-specific drug delivery and conjugation strategies

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light

• Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity

This product links an equatorial TCO to a hydroxyl group via a short PEG1 spacer specifically for rapid tetrazine ligation and versatile derivatization with minimal steric hindrance.