Tetrazine-Acid

Tetrazine-Acid

This product is a compact heterobifunctional reagent containing a tetrazine group and a terminal carboxylic acid. The tetrazine moiety supports ultrafast, copper-free inverse electron-demand Diels–Alder (IEDDA) ligation with strained alkenes such as TCO or BCN, while the carboxyl group couples readily with amines or activated esters. Its small, reactive design makes it especially useful for probe development, bioorthogonal chemistry, and controlled conjugation workflows.

Key Features and Benefits

• Tetrazine Group: Enables rapid, copper-free IEDDA ligation with strained alkenes.

• Carboxylic Acid Group: Couples efficiently with amines for stable amide bonds.

• Compact Design: Minimal spacing for efficient molecular incorporation.

• Dual Reactivity: Combines bioorthogonal click chemistry with classical amide coupling.

• High Purity: Produced to ≥95% purity for reproducibility.

Applications

• Bioconjugation: Links TCO/BCN-modified biomolecules with amine-functionalized partners.

• Protein and Antibody Labeling: Provides fast, selective bioorthogonal modification.

• Probe Development: Builds cleavable or dual-reactive probes for imaging and diagnostics.

• Drug Delivery: Serves as a linker for targeted therapeutic systems.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Prepare fresh solutions before use; avoid prolonged exposure to aqueous buffers.

This product integrates ultrafast click reactivity and amine coupling functionality in a compact scaffold, specifically offering versatility for chemical biology and therapeutic design.