APN-oxyamine HCl

APN-oxyamine HCl

APN-oxyamine HCl is a high-purity heterobifunctional reagent containing an aminooxy group for chemoselective oxime ligation with aldehydes and ketones, and an aminopentyl (APN) chain that provides flexibility and optimal spatial separation between reactive sites. The hydrochloride salt form enhances stability, solubility, and ease of handling. This reagent is especially ideal for site-specific labeling, surface functionalization, and the preparation of bioconjugates under mild, aqueous conditions.

Key Features and Benefits

• Aminooxy Group – Reacts selectively with carbonyl groups (aldehydes/ketones) to form stable oxime bonds without the need for harsh conditions.

• Aminopentyl Linker – Provides a flexible spacer that reduces steric hindrance, improving conjugation efficiency.

• Hydrochloride Salt Form – Improves stability, handling, and water solubility.

• High Purity – Supplied at >95% purity for consistent and reproducible performance.

Applications

• Oxime ligation for site-specific protein, peptide, and carbohydrate labeling

• Conjugation to aldehyde-functionalized surfaces, polymers, or nanoparticles

• Bioconjugation in antibody–drug conjugates (ADCs) and imaging probes

• Glycoconjugate synthesis and chemical biology research

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light

• Handling: Use in aqueous or aqueous–organic buffers at slightly acidic to neutral pH for optimal oxime formation; avoid prolonged exposure to moisture before use

This product is a high-purity, aminooxy-containing reagent with an aminopentyl spacer for especially efficient oxime ligation to aldehyde- or ketone-containing molecules. Its HCl salt form ensures stability, solubility, and reliable performance specifically in site-specific bioconjugation.