APN-BCN

APN-BCN

This product is a heterobifunctional linker containing an aminopropyl nitrile (APN) group and a bicyclo[6.1.0]nonyne (BCN) moiety. It specifically enables copper-free click chemistry with azides and orthogonal conjugation through the APN group, offering compact design and dual reactivity.

Key Features and Benefits

• BCN Group: Reacts rapidly with azides via SPAAC copper-free click chemistry.

• APN Group: Provides an orthogonal functional handle for further derivatization.

• Compact Scaffold: Minimizes steric hindrance while maintaining reactivity.

• Dual Reactivity: Combines bioorthogonal click chemistry with nitrile-based modification.

• High Purity: Ensures reproducibility in bioconjugation and synthetic workflows.

Applications

• Bioconjugation: Links azide-modified biomolecules with orthogonal partners.

• Probe Development: Builds multifunctional probes with bioorthogonal and APN handles.

• Drug Delivery: Provides PEG-like scaffolds with click-ready and orthogonal reactivity.

• Organic Synthesis: Serves as a versatile intermediate for modular linker design.

Storage and Handling

• Storage: Store at –20 °C in a sealed, light- and moisture-protected container.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.

This product integrates copper-free click chemistry with APN functionality in a compact scaffold, specifically offering solubility and versatile conjugation options.