TCO-PEG5 NHS ester

TCO-PEG5 NHS ester

TCO-PEG5 NHS ester is a high-purity heterobifunctional linker featuring a trans-cyclooctene (TCO) group for rapid, catalyst-free bioorthogonal tetrazine ligation and an NHS ester for efficient amine coupling. The PEG5 spacer specifically enhances solubility in aqueous and organic systems while reducing steric hindrance, enabling efficient conjugation in diverse applications.

Key Features

• TCO group for fast, catalyst-free tetrazine ligation

• NHS ester for stable amide bond formation with primary amines

• PEG5 spacer for improved solubility and reduced steric interference

Applications

• Bioorthogonal labeling and imaging

• Site-specific protein or antibody modification

• Preparation of multifunctional bioconjugates

Storage and Handling

• Store at –20 °C, protected from light and moisture

• Allow to warm to room temperature before opening to avoid condensation

This product combines fast bioorthogonal reactivity with efficient amine coupling, supported by a hydrophilic PEG5 spacer specifically for superior solubility and reduced steric hindrance. It is an especially ideal reagent for creating multifunctional, site-specific bioconjugates.